1. REAL-TIME ANALYTICAL SUPPORT FOLLOWED BY ISOLATION OF >4 KG OF THE ANTI-CANCER DRUG BREFELDIN-A, PRODUCED BY FERMENTATION OF EUPENICILLIUM BREFELDIANUM IN A 6,800 LITER TANK IN THE FERMENTATION PRODUCTION FACILITY OF CONSOLIDATED FERMENTATION SERVICES HERE AT FCRDC.
2. DEVELOP AN ANALYTICAL HPLC METHOD FOR QUANTITATION OF MICHELLAMINE A & B and KORUPENSAMINE A & B FROM SINGLE LEAF SPECIMENS OF ANCISTROCLADUS KORUPENSIS, AND PERFORM >1,200 ASSAYS IN SUPPORT OF A SURVEY OF THE WILD POPULATION OF PLANTS FROM CAMEROON TO IDENTIFY HIGH-PRODUCING PLANTS. THESE ANTI-HIV I & II, AND ANTI-MALARIAL ALKALOIDS WERE DISCOVERED FROM THIS SCREENING PROGRAM.
3. ISOLATION OF 4.4 GMS OF THE ANTI-CANCER COMPOUND ILLUDIN-M AND 100MG OF ILLUDIN-S, PRODUCED BY FERMENTATION OF THE FUNGUS OMPHALOTUS OLEARIS BY THE FPF.
4. ISOLATION OF 5.0 GMS OF THE ANTI-CANCER COMPOUND CUCURBITACIN E FROM SEEDS OF IBERIS AMARA (CRUCIFERAE).5. ISOLATION OF 705 MGS OF THE ANTI-CANCER LEAD JASPAMIDE WHICH COMES FROM A SOUTH PACIFIC SPONGE.
6. ISOLATION OF THE ANTI-CANCER LEAD COMPOUND NERIIFOLIN, CATALYTIC HYDROGENATION OF SOME OF IT TO YIELD A DERIVATIVE FOR TESTING, AND THE SURVEY BY HPLC OF SEVERAL DOZENS OF EXTRACTS TO DETERMINE THE BEST SOURCE OF ADDITIONAL COMPOUND.
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