Recent publications arising from the work of this group includes:  

 

Paul Klausmeyer, Gwendolyn N. Chmurny, Thomas G. McCloud,* Kenneth D. Tucker, and Robert H. Shoemaker: A Novel Antimicrobial Alkaloidfrom Aniba panurensis . Poster Presented at the 2004 International Congress on Natural Product Research, A joint meeting of the ASP, AFERP, GA and the PSE July 31-August 4, 2004 Phoenix, AZ.

M. Shipley,  A.L. Barr, S.J. Graf, R.P. Collins, T.G. McCloud, and D.J. Newman: Development of a Process for the Production of the Anticancer Lead Compound Pleurotin by Fermentation of Hohenbuehelia atrocaerulea.   Poster Presented at the 2004 International Congress on Natural Products Research, A joint meeting of the ASP, AFERP, GA and the PSE  July 31-August 4, 2004 Phoenix, AZ; Podium Presentation at the July 2004 Society of Microbiology meeting, Anaheim, CA.

Timothy J. Waybright and Thomas G. McCloud: Overcoming the Problems Associated with Long-Term Storage of Compounds in DMSO.  Presented at 2004 NCI-Frederick/Ft. Detrick Spring Research Festival, May 12-13, 2004 Ft. Detrick, Maryland  [Please Note: this is the Link to NSC Numbers]

Timothy J. Waybright and Thomas G. McCloud: pH Zone-Refining Countercurrent Chromatography for Resolution of Tropane Alkaloids and Applications for Preparative Scale Separations. Presented at 44th Annual Meeting of the American Society of Pharmacognosy “The Changing Face of Natural Products Chemistry” July 12-16, 2003 Chapel Hill, North Carolina

Rhone K. Akee, Suzanne M. Shipley, Sally J. Graf, David J. Newman and Thomas G. McCloud: Fermentation and Purification Methods for the Production of Leptomycin B and Related Analogs from Streptomyces SP.  Presented at 44th Annual Meeting of the American Society of Pharmacognosy “The Changing Face of Natural Products Chemistry” July 12-16, 2003 Chapel Hill, North Carolina

T. Luke Simmons and Thomas G. McCloud: Analysis of Stibonic Acids by Ion Exchange Chromatography with ESI-MS/Photodiode Array Detection.  Journal of Liquid Chromatography & Related Technologies 26(13) 2041-2051, 2003

Thomas G. McCloud, Barry R. O’Keefe, and Gordon Cragg: Bioactive Molecules From Water Extracts: 15 Years Experience at FCRDC. Presented at 44th Annual Meeting of the American Society of Pharmacognosy “The Changing Face of Natural Products Chemistry” July 12-16, 2003 Chapel Hill, North Carolina

Andrew G. Stephen, Karen W. Worthy, Eric Towler, Judy A. Mikovits, Shizuko Sei, Paula Roberts, Quan-en Yang, Rhone K. Akee, Paul Klausmeyer, Thomas G. McCloud, Lou Henderson, Alan Rein, David G. Covell, Micheal Currens, Robert H. Shoemaker, and Robert J. Fisher: Identification of HIV-1 Nucleocapsid Protein: Nucleic Acid Antagonists with Cellular Anti-HIV Activity. Biochemical and Biophysical Research Communications 296: 1228-1237, 2002

Paul Klausmeyer, T. Luke Simmons, Thomas G. McCloud:  Computer and Database Tools for the Identification of Novel Lead Compounds in Natural Products Extracts. Presented at the 43rd Annual Meeting of the American Society of Pharmacognosy and 3rd Monroe Wall Symposium July 27-31, 2002 Hyatt Regency Hotel, New Brunswick, New Jersey

Rhone K. Akee, Robert H. Shoemaker, and Thomas G. McCloud: Synthesis of  Fluorescein and Gallein and Gallein Derivatives: Physico-Chemical Properties.  Presented at the 43rd Annual Meeting of the American Society of Pharmacognosy and 3rd Monroe Wall Symposium July 27-31, 2002 Hyatt Regency Hotel, New Brunswick, New Jersey

Rhone K. Akee, Sally J. Graf, Thomas G. McCloud: The Diverse Toxins of  Aspergillus fumigatus MDH37025. Presented at the 43rd Annual Meeting of the American Society of Pharmacognosy and 3rd Monroe Wall Symposium July 27-31, 2002 Hyatt Regency Hotel, New Brunswick, New Jersey

Timothy J. Waybright, Thomas G. McCloud:  Isoelectric Focusing: A Novel Approach for Isolation of Small, Water-Soluble Molecules From Natural Products Extracts. Presented at the 43rd Annual Meeting of the American Society of Pharmacognosy and 3rd Monroe Wall Symposium July 27-31, 2002 Hyatt Regency Hotel, New Brunswick, New Jersey

McCloud, T.G., Klausmeyer, P, Newman, D.J:  Dereplication of Penicillium Bioactives Using Multidector HPLC and Bioactivity Profiles .  Presented at the American Society of Pharmacognosy Annual Meeting July 22-26, 2000, Seattle, WA.  {Please Note: To see a handout copy of this paper, please click on this link}PHandout.pdf

McCloud, T.G., Burnette, A. , Collins, R., Graf, S., Zhu, J., Reeb, S., Testerman, R., Wang, S. D., Newman, D. J: Development of a Process for the Production of the Anticancer Lead compound Wortmannin by the fermentation of Pencillium duclauxii.  Presented at the Third Conference on Recent Advances in Fermentation Technology, Sarasota, FL November 13-16, 1999.

McCloud, T.G., Britt, J.R., Cartner, L.K., Pearl, K.C., Majadly, F.D., Muschik, G.M., Klueh, P.A., Cragg, G.M., Thomas, D.W., Jato, J.G., Simon, J.E.: Quantitation of the Anti-HIV Alkaloids Michellamine A & B by HPLC.  Phytochemical Analysis 8: 120 - 123, 1997.

Simon, J.E.,Jato, J.C., Thomas, D.W., Symonds, P., Alkire, B.H., McCloud, T. C., Cragg, G.M., Morales, M.R., Foster, P.F., Miller, J.S., Gereau, R.E., (1996) “Investigations on Ancistrocladus korupensis: A Promising Source of Michellamine B from Cameroon”, J. Soc. Economic Botany 


Beutler,J.A., Alvarado-Lindner, A.B. and McCloud, T.G.:  Further studies on phorbol ester bioactivity in the Euphorbiaceae.  Annals of the Missouri Botanical Garden 83:530-533, 1996.

   

McCloud, T.G., Klueh, P.A., Pearl, K.C., Cartner, L.K.,  Muschik, G.M., Poole, K.K.  Isolation of illudin S from the mature basidiocarp of Omphalotus illudens, and isolation of  illudins S and M from the fermentation broth of Omphalotus olearis. Natural Product Letters 9: 87-95, 1996. 

 

McCloud, T.G., Burns, M.P., Majadly, F.D., Muschik, G.M., Miller, D.A., Poole, K.K., Roach, J.M., Ross, J.T., Lebherz,W.B., III:  Production of Brefeldin-A.  Jol. of  Industrial Microbiology 15: 5-9, 1995.

 

Chan, K.C., Majadly, F., McCloud, T.G., Muschik, G.M., Issaq, H.J. and Snader, K.M.: Micellar electrokinetic chromatography of the anti-human immunodeficiency virus (HIV) agent michellamine B with absorption and laser-induced  fluorescence detection.  Electrophoresis 15: 1310-1315, 1994.

Beutler, J.A., McKee, T.C., Fuller, R.W., Tischler, M., Cardellina, J.H.,II, McCloud, T.G., Snader, K.M. and Boyd, M.R.:  Frequent occurrence of HIV-inhibitory sulfated polysaccharides in marine invertebrates.  Antiviral Chem.& Chemotherapy 3: 167-172, 1993.

Schaufelberger, D.E., McCloud, T.G. and Beutler, J.A.: Laser-light-scattering detection for high-speed countercurrent chromatography. J. Chromatogr. 538(1): 87-90, 1991.

Beutler, J.A., Alvarado, A.B., Schaufelberger, D.E., Andrews, P. and McCloud, T.G.: Dereplication of phorbol bioactives: Lyngbya majuscula and Croton cuneatus.  J. Nat.Prod. 53: 867-874, 1990.       

Witherup, K.M., Look, S.A., Stasko, M.W., McCloud, T.G., Issaq, H.J., Muschik, G.M.:  High Performance liquid chromatographic separation of taxol and related compounds from Taxus brevifolia.  J. Liq. Chromatogr. 12(11), 2117-32,1989.  

Stasko, M.W., Witherup, K.M., Ghiorzi, T.J.,  McCloud, T.G., Look, S., Muschik, G.M., Issaq, H.J.:  Multimodal thin layer chromatographic separation of taxol and related compounds from Taxus brevifolia. J. Liq. Chromatogr. 12(11), 2133-  43, 1989. 

Beutler, J.A., Alvarado, A.B., McCloud, T.G. and Cragg,G.M.: Distribution of phorbol ester bioactivity in the Euphorbiaceae. Phytotherapy Res. 3: 188-192, 1989.  

 

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