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Natural Products Support Group

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NATURAL PRODUCTS SUPPORT GROUP

 

 

THE NATURAL PRODUCTS SUPPORT GROUP PROCESSES ALL PLANT, MARINE, AND FUNGAL SPECIMENS THAT ARE ACQUIRED BY THE DTP/NCI FOR SCREENING IN THE 60 HUMAN TUMOR ANTI-CANCER SCREEN AND OTHER  TEST SYSTEMS IN THE SEARCH FOR NEW DRUGS.  THE NPSG  PERFORMS A VARIETY OF OTHER TASKS AT THE REQUEST OF THE DTP, FOR EXAMPLE LARGE SCALE  GRINDING AND  EXTRACTING, LARGE SCALE ISOLATIONS, METHODS DEVELOPMENT, ANALYTICAL SUPPORT, GROWING AND OPTIMIZING OF FUNGAL CULTURES, AND IN VITRO AND IN VIVO DRUG PREPARATIONS. 

Natural Products Support Group includes the Extractions Lab, which processes higher plant, marine and fungal specimens for anti-cancer and anti-viral screening, a Drug Preperations Lab, which solubilizes drugs for in vitro and in vivo testing, and an Isolations Area which has chemists with expertise in natural products isolation, purification, structure elucidation and final product characterization for biologically active molecules.  An analytical method is often developed in the earliest stage of an isolations project, then used to maximize the yield by monitoring an extraction or fermentation as it is occurring.  Laboratory scale equipment is utilized to isolate enough material mass to validate purity, structure and biological activity.  Equipment is available and expertise exists within the Natural Products Area for the scale up of the isolation and purification steps to enable gram to kilogram amounts of product to be produced.

Examples of biologically active natural products isolated in quantity are brefeldin-A (multi kg), wortmannin, illudin-M (multi gram level), cucurbitacin-E (multi gram level), pleurotin, jaspamide, leptomycin, fumitremorgin-C .

 

Please click these links below for more information regarding Natural Products Lab.

Organization Chart     Discover     Recent Publications      NPSG Group Picture in renovated lab


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Request Form          DTP web site

 

 

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