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NATURAL PRODUCTS SUPPORT GROUP

 

 

CHEMISTRY: THE CHEMISTRY GROUP DOES ANALYTICAL SUPPORT, DEVELOPS EXTRACTION AND PROCESSING METHODS TO OBTAIN COMPOUNDS OF INTEREST TO DTP, AND PERFORMS SCALE-UP ISOLATIONS. PROJECTS HAVE INCLUDED:

            1.  REAL-TIME ANALYTICAL SUPPORT FOLLOWED BY ISOLATION OF >4 KG OF THE ANTI-CANCER DRUG BREFELDIN-A,   PRODUCED BY FERMENTATION OF EUPENICILLIUM BREFELDIANUM IN A 6,800 LITER TANK  IN THE FERMENTATION PRODUCTION FACILITY OF CONSOLIDATED FERMENTATION SERVICES HERE AT FCRDC.

            2.  DEVELOP AN ANALYTICAL HPLC METHOD FOR QUANTITATION OF MICHELLAMINE A & B and KORUPENSAMINE A & B FROM SINGLE LEAF SPECIMENS OF ANCISTROCLADUS KORUPENSIS, AND PERFORM >1,200 ASSAYS IN SUPPORT OF A SURVEY OF THE WILD POPULATION OF PLANTS FROM CAMEROON TO IDENTIFY HIGH-PRODUCING PLANTS.  THESE ANTI-HIV I & II, AND ANTI-MALARIAL ALKALOIDS WERE DISCOVERED FROM THIS SCREENING PROGRAM.

            3.  ISOLATION OF 4.4 GMS OF THE ANTI-CANCER COMPOUND ILLUDIN-M AND 100MG OF ILLUDIN-S, PRODUCED BY FERMENTATION OF THE FUNGUS OMPHALOTUS OLEARIS BY THE FPF.

            4.  ISOLATION OF 5.0 GMS OF THE ANTI-CANCER COMPOUND CUCURBITACIN E FROM SEEDS OF IBERIS AMARA (CRUCIFERAE).

            5. ISOLATION OF 705 MGS OF THE ANTI-CANCER LEAD JASPAMIDE WHICH COMES FROM A SOUTH PACIFIC SPONGE.

           6.  ISOLATION OF THE ANTI-CANCER LEAD COMPOUND NERIIFOLIN, CATALYTIC HYDROGENATION OF SOME OF IT TO YIELD A DERIVATIVE FOR TESTING, AND THE SURVEY BY HPLC OF SEVERAL DOZENS OF EXTRACTS TO DETERMINE THE BEST SOURCE OF ADDITIONAL COMPOUND.

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