WELCOME TO THE NPSG
The Natural Products Support Group provides support and services to the Developmental Therapeutics Program (DTP), Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute. The Extract Production Lab carries out all grinding, extraction, drying and freeze drying of plant, marine and fungal specimens. The Fungal Metabolites Lab performs fermentations for screening, assures culture purity, performs cryopreservation of fungal stocks, optimizes titre of bioactive metabolites, produces co-cultures to search for new compounds, and carries out scale-up fermentations for drug production. The Drug Processing Lab weighs pure chemicals and extracts; produces both 96-well and 384-well microtiter plates of extracts and pure drugs for storage and anticancer screening; ships and receives extracts, drugs, and plates; develops solubilization methods; and processes and delivers extracts and drugs for animal testing. The Methods Development and Isolation Laboratory provides analytical support, purity and identity analysis, de-replication of bioactive extracts, purifies compounds of interest for testing, identifies new natural products, makes chemical modifications of compounds with biological activity, and performs scale-up isolations of compounds of interest to the DTP for further biological evaluation.
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